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Supplement may boost response to antidepressants
Last Updated: 2004-12-03 8:55:00 -0400 (Reuters Health)
By Amy Norton
NEW YORK (Reuters Health) - When standard medication fails to improve depression symptoms, adding the dietary supplement SAMe may help, preliminary research suggests.
The study involved 30 patients with persistent depression despite treatment with selective serotonin reuptake inhibitors (SSRIs) such as Prozac, Paxil and Zoloft, or with the drug Effexor, another type of antidepressant.
The researchers found that when they added the dietary supplement SAMe to the patients' treatment for six weeks, half saw their symptoms improve and 43 percent had a complete remission.
The findings are published in the December issue of the Journal of Clinical Psychopharmacology.
SAMe, short for S-adenosyl-L-methionine, is a substance produced naturally in the body that is involved in a number of biochemical processes including the synthesis of brain chemicals called neurotransmitters that relay messages between nerve cells. Serotonin, the prime target of antidepressant drugs, is one such neurotransmitter.
While the new findings suggest that SAMe may enhance a person's response to antidepressant therapy, the study was an "open trial" -- meaning all patients received SAMe and there was no group that received an inactive placebo for comparison purposes.Read More....
Reuters Health - headlines
Supplement may boost response to antidepressants
Last Updated: 2004-12-03 8:55:00 -0400 (Reuters Health)
By Amy Norton
NEW YORK (Reuters Health) - When standard medication fails to improve depression symptoms, adding the dietary supplement SAMe may help, preliminary research suggests.
The study involved 30 patients with persistent depression despite treatment with selective serotonin reuptake inhibitors (SSRIs) such as Prozac, Paxil and Zoloft, or with the drug Effexor, another type of antidepressant.
The researchers found that when they added the dietary supplement SAMe to the patients' treatment for six weeks, half saw their symptoms improve and 43 percent had a complete remission.
The findings are published in the December issue of the Journal of Clinical Psychopharmacology.
SAMe, short for S-adenosyl-L-methionine, is a substance produced naturally in the body that is involved in a number of biochemical processes including the synthesis of brain chemicals called neurotransmitters that relay messages between nerve cells. Serotonin, the prime target of antidepressant drugs, is one such neurotransmitter.
While the new findings suggest that SAMe may enhance a person's response to antidepressant therapy, the study was an "open trial" -- meaning all patients received SAMe and there was no group that received an inactive placebo for comparison purposes.Read More....
Reuters Health - headlines
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